Associations between distinct trajectories of body mass index (BMI) over 15 years preceding dementia and incidence of dementia

Background BMI has been reported to associate with dementia, both increased and decreased risks. The purpose of this study was examine longitudinal distinct trajectories over 15 years preceding dementia incident using the large national dataset from National Alzheimer’s Coordinating Center (NACC). Method We used NACC 2005 December 2020 performed a nested case-control (up 1 4 match). sample included 699 cases all-causes at least 5–years follow-up time diagnosis, 2120 non-dementia controls matched on age, sex, race, education baseline cognitive status. A group-based trajectory model applied identify groups among sample. Conditional logistic regression evaluate effect BMI, APOE genotype interaction between them dementia. Result For case group (n = 699), mean age enrollment 75.5 average in 16.1, participants were more female (58.8%), non-Hispanic white (86.8%) healthy status initial visit (64%). three-group linear best fit before onset that featured normal weight-decreasing (45.5%), overweight-decreasing (43.6%) obese-decreasing (10.9%). There is statistically significant decreasing trend for each (P<0.0001). 22.7, 29.9 36.7 respectively. revealed genotype. Comparing ε4 non-carriers, carriers either or likely develop [OR 1.53, 95% CI (1.00-2.34), P 0.05; OR 1.88, (1.06-3.34), 0.03]. Especially, within had triple likelihood ([OR 3.25, (2.13-4.94), P<0.0001]. Conclusion Our findings suggest existence developmental possible gene-environment exhibited highest risk